Methods for identifying oligonucleotides having a desired activity in vivo are disclosed. In accordance with preferred embodiments, oligonucleotides capable of conferring a desired phenotype are identified. Therapeutic, diagnostic and research methods and compositions employing such oligonucleotides are provided. Prior knowledge of the sequence or structure of a target molecule is generally not required.
申请公布号
WO9516054(A1)
申请公布日期
1995.06.15
申请号
WO1994US13884
申请日期
1994.12.02
申请人
MIRABELLI, CHRISTOPHER, K.;ECKER, DAVID, J.;VICKERS, TIMOTHY, A.;ROBERTSON, DEBRA, L.
发明人
MIRABELLI, CHRISTOPHER, K.;ECKER, DAVID, J.;VICKERS, TIMOTHY, A.;ROBERTSON, DEBRA, L.