发明名称 |
NOVEL STAPHYLOCOCCUS PEPTIDES FOR BACTERIAL INTERFERENCE |
摘要 |
The present invention provides a cyclic peptide comprising structure (I) wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2-X(n)-Z-X(y)-COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed. |
申请公布号 |
WO9967286(A2) |
申请公布日期 |
1999.12.29 |
申请号 |
WO1999US14562 |
申请日期 |
1999.06.24 |
申请人 |
THE ROCKEFELLER UNIVERSITY;NEW YORK UNIVERSITY;MUIR, TOM, W.;MAYVILLE, PATRICIA;NOVICK, RICHARD, P.;JI, GUANGYONG;BEAVIS, RONALD |
发明人 |
MUIR, TOM, W.;MAYVILLE, PATRICIA;NOVICK, RICHARD, P.;JI, GUANGYONG;BEAVIS, RONALD |
分类号 |
A61K38/00;A61P31/04;C07K14/31 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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