SUSTAINED RELEASE ORAL PREPARATIONS OF FASUDIL HYDROCHLORIDE

摘要

Sustained release oral preparations containing at least one active ingredient selected from the group consisting of fasudil hydrochloride and its hydrate. These preparations are characterized by containing at least one sustained release coated particle consisting of a core having surface and a film coating the surface of the core; the core containing the above-mentioned active ingredient(s) while the film containing a coating base and a specific insoluble substance; and showing a specific elution ratio of the active ingredient(s) when tested by the elution method. By using these preparations, the elution of the active ingredient(s) from the preparations can be surely controlled and the effects of the active ingredient(s) can be sustained over a long period of time, thereby relieving the burden loaded upon patients due to the administration of drugs and improving the compliance. A method for evaluating sustained release oral preparations regarding the ability to release the active ingredient(s).