发明名称 |
GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS |
摘要 |
The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by general Formulae (I-III) wherein R1-R5 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I-III) are activators of caspases and inducers of apoptosis . Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditio ns in which uncontrolled cell growth and spread of abnormal cells occurs.</SDOA B>
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申请公布号 |
CA2396005(A1) |
申请公布日期 |
2000.08.03 |
申请号 |
CA20002396005 |
申请日期 |
2000.02.01 |
申请人 |
CYTOVIA, INC. |
发明人 |
TSENG, BEN;KASIBHATLA, SHAILAJA;DREWE, JOHN A.;WANG, YAN;ZHANG, HAN-ZHONG;CAI, SUI XIONG |
分类号 |
A61K31/352;A61K31/4025;A61K31/4178;A61K31/4188;A61K31/4433;A61K31/453;A61K31/496;A61K31/497;A61K31/5377;A61K31/5513;C07D493/20;C07D493/22;C07D519/00;(IPC1-7):A61K31/402;A61P1/00;A61P17/00;A61P35/00;A61P19/02;A61P37/02;A61P17/06;C07D493/18;A61K31/415;A61K31/417;A61K31/445;A61K31/537;A61K31/55 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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地址 |
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