| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention pertains to new 7-azaindoles with general formula 1: where (a) A stands for an N-oxide group and B stands for CH, nitrogen, (b) A stands for nitrogen and B stands for an N-oxide group, or (c) A and B stand for an N-oxide group, R1 stands for (i) -C1-10-alkyl, unbranched or branched, which, if necessary, is monosubstituted with saturated mono- C3-C6carbocycle, or mono-, bi- multi-unsaturated C6-C10carbocycle. C6-10-aryl groups in turn, if necessary, can be mono- or multi-substituted with -C1-6-alkyl, -CN, -F, -CI, -Br, -I, -O-C1-6-alkyl groups. Alkyl groups in carboxylic substitutes, in turn, if necessary, can be mono- or multi-substituted with -F groups. R2 stands for hydrogen, C1-C3alkyl. R3 and R4 are identical or different, and stand for hydrogen, -F, -Cl, -Br, -I. The invention also relates to pharmaceutical salts of these 7-azaindoles. ^ EFFECT: compounds with general formula I exhibit phosphodiesterase 4 inhibiting activity, which allows for their use as therapeutic active substances for making medicinal agents, which suppress pulmonary neutrophilia and eosinophilia. ^ 14 cl, 2 tbl, 7 ex |
