Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2. See Figure 1. Pph 3 FmocHN 0FmocHN OH cl-S Me' O Me Pph 3 Fmoc-R8 Fmoc-S5
申请公布号
AU2016210709(A1)
申请公布日期
2016.08.25
申请号
AU20160210709
申请日期
2016.08.04
申请人
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人
BERNAL, FEDERICO;WALENSKY, LOREN D.;VERDINE, GREGORY L.;KORSMEYER, STANLEY
