| 摘要 |
1,235,684. Basic alcohols, ethers and esters. CENTRE DE RECHERCHES MARCEL MIDY. 15 Nov., 1968 [21 Nov., 1967], No. 52985/67. Heading C2C. Compounds of the general formula (Z=CH 2 CH 2 , CH=CH, CH 2 CH 2 CH 2 , CH 2 CH= CH; R=H, saturated or unsaturated C 1-8 aliphatic group, R 2 CO; R 2 =saturated or unsaturated C 1-6 aliphatic group, or Ph, phenylalkyl, PhOCH 2 , PhSCH 2 optionally ring- substituted by 1-3 substituents selected from Me, alkoxy, halogen; R 1 =Ph, PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino optionally ring - substituted by 1 or 2 substituents selected from NO 2 , NH 2 , halogen, alkyl, alkoxy and C 5-6 cycloalkyl, 2 - naphthyl, 1,2,3,4 - tetrahydro - 6 - naphthyl, C 5-6 cycloalkyl, alkoxy, alkylthio; n=0-2; provided that R 1 =PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino, optionally substituted, only when Z=CH 2 CH 2 or CH=CH) and their acid addition salts are prepared by the following reactions: optionally followed by etherification or esterification and/or salt formation. The preparation of the heterocyclic starting materials by standard methods is described. The above compounds have sympathicolytic, myolytic, psychotropically tranquillizing and analgesic and local anaesthetic activity and may be administered in the form of pharmaceutical preparations contaning them in association with a carrier. |
