| 摘要 |
1526617 Tyrosine derivatives G D SEARLE & CO 6 May 1977 [7 May 1976] 19212/77 Heading C2C [Also in Division C3] 5-Aminopentanoic acid, benzyl alcohol and ptoluenesulphonic acid monohydrate are reacted to yield 5-aminopentanoic acid benzyl ester, ptoluenesulphonic acid salt. Similarly, there are prepared: 6-aminohexanoic acid benzyl ester, p-toluenesulphonic acid salt; 4-aminobenzoic acid benzyl ester, p-toluenesulphonic acid salt; 4-aminocyclohexanecarboxylic acid benzyl ester, p-toluenesulphonic acid salt. t - Butoxycarbonyl - L - tyrosine is reacted with 5-aminopentanoic acid benzyl ester, ptoluenesulphonic acid salt to yield N-t-butoxycarbonyl - L - tyrosyl - 5 - aminopentanoic acid benzyl ester which is hydrogenolysed over palladium black to yield N-t-butoxycarbonyl-L- tyrosyl-5-amniopentanoic acid. Similarly, there are prepared: N-t-butoxycarbonyl - L - tyroayl - 6 - aminohexanoic acid, N - t - butoxycarbonyl - L - tyrosyl - 4 - aminobenzoic acid, N - t - butoxycarbonyl - L - tyrosyl- 4 - aminocyclohexanecarboxylic acid. |
