发明名称 ESCULETIN DERIVATIVES, METHOD FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITION
摘要 A compound of the formula (I): <IMG> (I) wherein R1 and R2 are, independently, -CON(R4)R5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R1 and R2 is -CON(R4)R5, and R4 and R5 are, independently, a hydrogen atom, or a hydroxyl, alkyl, aryl, or aralkyl group, or R4 and R5 together with the nitrogen atom attached thereto form a 3- to 7-membered saturated cycloaliphatic amino group, and R3 is a hydrogen atom, or a hydroxyl, alkyl, aryl, aralkyl, or -COOR8 group, and R3 is at 3- or 4-position, and R8 is a hydrogen atom or an alkyl group, or a salt thereof is disclosed. The compound has a function to inhibit a matrix metalloproteinase.
申请公布号 CA2166168(A1) 申请公布日期 1996.06.29
申请号 CA19952166168 申请日期 1995.12.27
申请人 KUREHA CHEMICAL INDUSTRY CO., LTD. 发明人 WATANABE, KOJU;NIIMURA, KOICHI;YAMAZAKI, TORU;MARUOKA, HIROSHI
分类号 C12N9/99;A61K31/365;A61K31/535;A61K31/70;A61K31/7042;A61K31/7048;A61P1/02;A61P11/00;A61P13/02;A61P15/00;A61P17/00;A61P27/02;A61P29/00;A61P43/00;C07D311/16;C07H1/00;C07H17/075;(IPC1-7):C07H15/26;C07D405/12;A61K31/395;A61K31/37;C07D413/12 主分类号 C12N9/99
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