发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV VAESENTLIGEN RENT INTERLEUKIN-2 PROTEIN. |
摘要 |
A substantially pure non-glycosylated human interleukin-2 protein (I) with a specific activity of at least 10,000 U/mg is new. (I) has an amino acid sequence as shown in the figure, where X = Met or H. A bacterial transformant contg. a DNA sequence coding for human interleukin-2, esp. E. coli DHI/pTF4 (IFO 14299, FERM BP628), is cultured to accumulate (I) in the broth, which is purified by hydrophobic column chromatography, esp. reverse-phase HPLC. |
申请公布号 |
FI81118(B) |
申请公布日期 |
1990.05.31 |
申请号 |
FI19840004678 |
申请日期 |
1984.11.28 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
KATO, KOICHI;YAMADA, TAKAO;ONDA, HARUO |
分类号 |
C12N15/09;A61K38/00;A61P35/00;A61P37/04;C07K1/20;C07K7/23;C07K14/00;C07K14/52;C07K14/54;C07K14/55;C12N15/26;C12P21/02;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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