发明名称 |
Isostere anti-herpes peptid-derivater |
摘要 |
Disclosed herein are peptide derivatives of the formula A-B-D-CH2CH{CH2C(O)R<1>}C(O)NHCH{CR<2>(R<3>)COOH}C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl, and B is a N-methyl amino acid residue; or A and B together form a saturated or unsaturated alkylaminocarbonyl; D is an amino acid residue; R<1> is alkyl, cycloalkyl, a monosubstituted or a disubstituted amino; R<2> is hydrogen or alkyl and R<3> is alkyl, or R<2> is hydrogen and R<3> is phenylalkyl, or R<2> and R<3> are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections. |
申请公布号 |
NO943345(D0) |
申请公布日期 |
1994.09.09 |
申请号 |
NO19940003345 |
申请日期 |
1994.09.09 |
申请人 |
BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC |
发明人 |
BEAULIEU, PIERRE LOUIS;DEZIEL, ROBERT;MOSS, NEIL;PLANTE, RAYMOND |
分类号 |
A61K31/495;A61K31/16;A61K38/00;A61K38/04;A61P31/12;A61P31/22;C07C237/20;C07C237/22;C07C271/22;C07C275/42;C07D295/10;C07D295/185;C07K1/113;C07K5/02;C07K5/06;C07K5/072;(IPC1-7):C07K5/02;A61K37/02;A61K31/13;C07K5/10 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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