发明名称 |
SIGMA-1 RECEPTOR LIGAND WITH ACETYLCHOLINESTERASE INHIBITION PROPERTIES |
摘要 |
A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against beta-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-l receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant. |
申请公布号 |
WO2005016276(A2) |
申请公布日期 |
2005.02.24 |
申请号 |
WO2004US25295 |
申请日期 |
2004.08.05 |
申请人 |
SAMARITAN PHARMACEUTICALS INC.;GEORGETOWN UNIVERSITY;PAPADOPOULOS, VASSILIOS;LECANU, LAURENT;GREESON, JANET |
发明人 |
PAPADOPOULOS, VASSILIOS;LECANU, LAURENT;GREESON, JANET |
分类号 |
A61K;A61K31/56 |
主分类号 |
A61K |
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