| 发明名称 |
INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF |
| 摘要 |
The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
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| 申请公布号 |
US2009076076(A1) |
申请公布日期 |
2009.03.19 |
| 申请号 |
US20080138806 |
申请日期 |
2008.06.13 |
| 申请人 |
BAYLOR UNIVERSITY |
发明人 |
SILES ROGELIO;ZHOU MING;ACKLEY J. FREELAND;PINNEY KEVIN G.;CHEN SHEN-EN;ARISPE-ANGULO WARA MILENKA;TRAWICK MARY LYNN |
| 分类号 |
A61K31/47;A61K31/18;A61K31/382;C07C337/06;C07D215/00;C07D335/06 |
主分类号 |
A61K31/47 |
| 代理机构 |
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