发明名称 |
A METHOD OF RATIONAL ANTIBODY DESIGN |
摘要 |
We describe a method for the rational design of complementary peptides that can bind with high specificity and affinity to target regions of a protein molecule or sequence. The method uses a computational algorithm that exploits the availability of a large number of experimentally-derived protein structures to identify potential interaction partners. We also describe grafting the designed sequences into protein scaffolds, such as an antibody scaffold. |
申请公布号 |
WO2016091765(A2) |
申请公布日期 |
2016.06.16 |
申请号 |
WO2015EP78728 |
申请日期 |
2015.12.04 |
申请人 |
CAMBRIDGE ENTERPRISE LIMITED |
发明人 |
VENDRUSCOLO, MICHELE;SORMANNI, PIETRO;APRILE, FRANCESCO |
分类号 |
G06F19/16;G06F19/22 |
主分类号 |
G06F19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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