发明名称 |
CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS |
摘要 |
The present invention provides for methods of using terf-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery. |
申请公布号 |
CA2702243(C) |
申请公布日期 |
2016.06.21 |
申请号 |
CA20082702243 |
申请日期 |
2008.09.05 |
申请人 |
US WORLDMEDS LLC |
发明人 |
MALKAWI, AHMAD;AL-GHANANEEM, ABEER M.;DELUCA, PATRICK;DIGENIS, GEORGE A. |
分类号 |
A61K9/08;A61K9/00;A61K9/19 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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