| 主权项 |
1. A compound of Formula I or II, or a pharmaceutically acceptable salt thereof,wherein:
Q is O; Z is —C(═O)—; R1 is a phenyl group, and the phenyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —OH, —NO2, —NHC(═O)C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, —(CH2)nC(═O)Rf, —(CH2)nC(═O)NRfRf, —CN, —NRgRg or A, each A is independently a 5 or 6 membered aryl or heteroaryl group, which heteroaryl group can contain from one to three heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; R2 is a phenyl group, and the phenyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —OH, —NO2, —NHC(═O)C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, —(CH2)nC(═O)Rf, —(CH2)nC(═O)NRfRf, —CN, —NRgRg or B, each B is independently a 5 or 6 membered aryl or heteroaryl group, which heteroaryl group can contain from one to three heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; R2a is hydrogen or —C1-3alkyl; R3 is hydrogen, —C1-6alkyl, —C(═O)ORf, —C(═O)C1-6alkyl, —S(═O)2Rf, —S(═O)Rf, —ORf, —C(═O)NRfN(Rf)2, —C(═O)NRfS(═O)2Rf, —S(═O)2NRfC(═O)Rf, —S(═O)2NRfRf, —N(Rf)C(═O)NRfRf, —NRfCO2Rf, —C(═O)NRfRf, —NRfS(═O)2Rf, —CN, —NRfRf, —C(═O)NOH, —NRfC(═O)ORf, —NRfC(═O)Rf, —C1-6alkyl substituted with from 1 to 3 hydroyl groups, —C1-6alkenyl, or a 5 or 6 membered aryl or heteroaryl group, which heteroaryl group can contain from one to four heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN, and any C1-6alkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —OH, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; R4 is —C2-6alkenyl, —CF3, —CH2F, —CHF2, —S(═O)2Rf, —SRf, —S(═O)Rf, —S(═O)2NRfRf, —NRfS(═O)2NRfRf, —C(═O)NRfRf, —NRfS(═O)2Rf, —CO2Rf, —ORf, a 3 to 7 membered cycloalkyl or heterocycloalkyl, optionally containing a —(C═O)— group, or a 5 to 6 membered aryl or heteroaryl group, which heterocycloalkyl or heteroaryl group can contain from one to three heteroatoms independently selected from O, N or S, and the cycloalkyl, heterocycloalkyl, aryl or heteroaryl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl —OH, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN, and the —C1-6alkyl or —C2-6alkenyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —NRfRf, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; R5 is hydrogen or —C1-6alkyl; R6 is hydrogen, —C1-6alkyl, —(CH2)n—NRfRf, or —(CH2)nC(═O)NRfRf; each Ra is independently hydrogen, halo or —C1-6alkyl, or two Ra groups that are attached to the same carbon atom can form an (═O) group or a 3 to 6 membered cycloalkyl or heterocycloalkyl group, or an Ra group and R6 along with the atoms to which they are attached can form a 3 to 6 membered cycloalkyl or heterocycloalkyl group, which heterocycloalkyl group can contain from one to two heteroatoms independently selected from O, N or S, and the cycloalkyl or heterocycloalkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; each Rc is independently hydrogen, —C1-6alkyl, —C1-6alkyl-CF3, —CF3, a 3 to 6 membered cycloalkyl or heterocycloalkyl group, which heterocycloalkyl group can contain from one to two heteroatoms independently selected from O, N or S, and the cycloalkyl or heterocycloalkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; or two Rc groups that are attached to the same or adjacent carbon atoms can together with the carbon atom or atoms to which they are attached form or a 3 to 6 membered cycloalkyl or heterocycloalkyl group, which heterocycloalkyl group can contain from one to two heteroatoms independently selected from O, N or S, and the cycloalkyl or heterocycloalkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; each Rd is independently hydrogen or —C1-6alkyl; each Re is independently hydrogen or —C1-6alkyl; each Rf is independently hydrogen, —CN, —C1-6alkyl, —C1-6alkyl-CN, —C1-6alkyl-CF3, hydroxyC1-6alkyl, —C1-6alkylNReRe, or a 5 to 6 membered aryl, —C1-6alkylaryl, heteroaryl, or —C1-6alkylheteroaryl, or a 3 to 9 membered cycloalkyl, —C1-6alkylcycloalkyl, heterocycloalkyl or —C1-6alkylheterocycloalkyl group, which heteroaryl, alkylheteroaryl, heterocycloalkyl, or alkylheterocycloalkyl group can contain from one to three heteroatoms independently selected from O, N or S, and the alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, or alkylheterocycloalkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; or when Rf and Rf are part of an NRfRf or CRfRf moiety in a group, then Rf and Rf together with the nitrogen or carbon atom to which they are attached can form a 3 to 7 membered heterocycloalkyl or cycloalkyl group, which heterocycloalkyl group can contain from one to two additional heteroatoms independently selected from O, N or S, and the heterocycloalkyl or cycloalkyl group can be unsubstituted or substituted with from one to three substituents independently selected from halo, —C1-6alkyl, —S(═O)2C1-6alkyl, —S(═O)C1-6alkyl, —OC1-6alkyl, —CF3, —OCF3, —OCHF2, —OCH2F, or —CN; each Rg is independently hydrogen, or —C1-6alkyl; and each n is independently 0, 1, 2, 3 or 4, provided that the compound is not 2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S,2S)-2-(isopropylsulfonyl)cyclopentyl)-3-oxomorpholin-2-yl)acetic acid; 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S,2S)-2-(isopropylsulfonyl)cyclopentyl)-3-oxomorpholin-2-yl)acetic acid; 2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R,2R)-2-(isopropylsulfonyl)cyclopentyl)-3-oxomorpholin-2-yl)acetic acid; or 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R,2R)-2-(isopropylsulfonyl)cyclopentyl)-3-oxomorpholin-2-yl)acetic acid. |
