Substituted pyridine spleen tyrosine kinase (SYK) inhibitors

摘要

The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.;

主权项

1. A compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein
R1 is selected from the group consisting of C1-C3 fluoroalkyl;R2 is H;R3 is H;R4 is selected from the group consisting of C1-C3 alkyl and —N(H)C(O)R4b;
R4b is C1-C3 alkyl;Cy is t is 1;Rcy is a group of the formula  wherein
Y1 is a bond;D1 is a 4- to 8-membered mono- or bicyclic heterocyclic ring optionally containing one additional heteroatom selected from the group consisting of N and S;each R10 is independently selected from the group consisting of C1-C3 alkyl, hydroxyl, —CO2H, —CH2CO2Rg, —C(O)N(H)—(CH2CO2H), or wherein when two R10 moieties are geminally substituted on a common ring carbon atom of D1, the two geminally substituted R10 moieties together with the carbon atom on which they are attached form —C(O)—;
Rg is H or C1-C3 alkyl; andq is 1.