1, 2, 4-triazole derivatives and their anti-microbial activity

摘要

Triazole derivatives useful as anti-tubercular compounds; process for preparation of the triazoles and a method for inhibiting growth of Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Ra using the triazoles.

主权项

1. A compound of General Formula I wherein, X is sulfur (S) or a sulphone n is 1, m is 1; R1 is selected from the group consisting of hydrogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group; halogen; and aryl group optionally substituted with —OCH3, halogen, or nitro; R2 and R3 are selected from the group consisting of hydrogen, and C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 3 carbon atoms; and Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 5 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, wherein heterocyclic ring is substituted with arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, allyl or propargyl groups consisting of 3 carbon atoms.