miRNA-212/132 family as a therapeutic target

摘要

The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis, treatment or prevention of cardiac disorders, e.g. cardiac hypertrophy-associated or autophagic disorders, and further refers to isolated nucleic acid molecules, particularly microRNAs miR-212 and/or miR-132 and related sequences, for use in medicine, particularly human medicine, more particularly in the diagnosis, treatment or prevention of disorders involving cardiac atrophy and/or dysfunctional autophagy, e.g. cardiac cachexia.

主权项

1. A pharmaceutical composition comprising
a) an inhibitor of miR-132 wherein the inhibitor is an isolated nucleic acid molecule comprising at least one modified building block, and b) a further medicament selected from the group consisting of angiotensin-modulating agents, β-blockers, diuretics, aldosterone antagonists, vasodilators, ionotrophic agents and combinations thereof.