发明名称 | Crystalline, anhydrous forms of oxymorphone hydrochloride | ||
摘要 | Crystalline, anhydrous hydrochloride salts of 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain. | ||
申请公布号 | US9440986(B2) | 申请公布日期 | 2016.09.13 |
申请号 | US201514613421 | 申请日期 | 2015.02.04 |
申请人 | ENDO PHARMACEUTICALS INC. | 发明人 | Fischer Andreas;Peters-Groth Dagmar;Lischke Dagmar |
分类号 | A61K31/485;C07D489/08 | 主分类号 | A61K31/485 |
代理机构 | Mayer Brown LLP | 代理人 | Mayer Brown LLP |
主权项 | 1. A crystalline, anhydrous hydrochloride salt of 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one according to formula (I): wherein the hydrochloride salt exhibits an X-ray powder diffractogram wherein peaks are observed at a grouping of peaks selected from the group consisting of A and B: A) at (±0.2 in 2θ): 9.2, 12.7, 13.8, 14.7, 15.3, 16.2, 17.1, 19.0, 19.9, 20.6, 21.7, 24.6, 31.9 and 34.6; andB) (±0.2 in 2θ): 6.0, 12.1, 13.1, 13.6, 15.3, 16.5, 22.4, 22.6, 24.1 and 29.8. | ||
地址 | Malvern PA US |