Disubstituted triazole analogs

摘要

The present disclosure describes disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided, examples include 4,5-diaryl-1,2,3-triazoles, 4-aryl-5-heteroaryl-1,2,3-triazoles. These compounds are synthesized by treating diaryl or aryl-heteroaryl substituted olefins with azides in the presence of a proton donor or acceptor. The inhibition of tubulin polymerization using these 1,2,3-triazoles is also described.