| 摘要 |
<p>A substrate such as a catheter or a guide wire is provided with a lubricous, hydrophilic abrasion-resistant coating by: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a first polymer having organic acid functional groups and a first polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups, and drying said first coating composition to obtain a substantially water-insoluble coating layer still including functional groups being reactive with organic acid groups; and b) contacting said dried coating layer with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, a second polymer having organic acid functional groups, and a second polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups, and drying to effectuate covalent bonding of said hydrophilic polymer and said second polymer to said first polymer of the first coating composition through said first or said second crosslinking agents to form a hydrophilic coating; wherein said first polymer and said second polymer may be the same or different, and further wherein said first crosslinking agent and said second crosslinking agent may be the same or different. The drying can be carried out at ambient (room) temperature.</p> |
