发明名称 |
METHODS AND COMPOSITIONS FOR DETECTING AND TREATINMETHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN AHPCF OPERON G MYCOBACTERIAL INFECTIONS USING AN AHPCF OPERON |
摘要 |
The embodiments of the invention are based upon the identification and characterization of an operon that determines mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. This operon, termed <u>ahpCF</u>, encodes polypeptides, AhpC and AhpF, which likely combine to form an active alkyl hydroperoxide reductase enzyme that may either be a direct target for INH or act to confer INH resistance. The sequence of the mutant <u>ahpCF</u> operon is provided, showing that INH resistance can be conferred by a mutation in the promoter region. Also provided are polynucleotides and polypeptides that are useful in diagnosis and treatment. |
申请公布号 |
WO9619578(A3) |
申请公布日期 |
1996.08.29 |
申请号 |
WO1995NZ00133 |
申请日期 |
1995.12.20 |
申请人 |
NEW ZEALAND PASTORAL AGRICULTURE RESEARCH INSTITUT;COLLINS, DESMOND, MICHAEL;WILSON, THERESA |
发明人 |
COLLINS, DESMOND, MICHAEL;WILSON, THERESA |
分类号 |
A61K38/00;A61K39/00;C12N9/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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