摘要 |
<p>"Dihydropyridine anti-ischaemic and antihypertensive agents" 1,4 Dihydropyridine derivatives of the formula: (I) wherein R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; n is 1 to 3, and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C1-C4 alkyl, phenyl, benzyl, CN, -N(R3)2, (CH2)mCO2H, (CH2)mCO2(C1-C4 alkyl) or (CH2)mCON(R3)2 group wherein each R3 is independently H or C1-C4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.</p> |