| 摘要 |
<p>Substantially pure mammalian proteins having the following characteristics are disclosed: (a) molecular weight of approximately 110,000 Daltons; (b) bind HDL3; (c) bind apoA-I proteoliposomes and apoA-II proteoliposomes; and (d) contain approximately 10 % carbohydrate by weight. The present invention also discloses a substantially pure protein having the following characteristics: (a) a molecular weight of approximately 38,000 Daltons; (b) binds HDL3; and (c) contains approximately 331 amino acid residues. DNA sequences encoding these proteins, as well as cells transfected or transformed with an expression vector containing such a DNA sequence are also disclosed. Antibodies that bind to these proteins, methods for isolating an HDL3-binding protein and methods for detecting a genetic defect in an HDL-binding protein in a patient are also disclosed.</p> |
