DEVICE FOR ADMINISTERING AN ACTIVE AGENT TO THE SKIN OR MUCOSA

摘要

A transdermal drug delivery device (11) comprising a drug formulation-containing reservoir (13) defined by a backing layer (12) and a drug-permeable membrane layer (16), a peelable inner liner (20) that underlies the reservoir and a portion of the backing/ membrane outwardly of the reservoir periphery, an adhesive layer (15) that underlies the inner liner and outwardly extending portions of the membrane/backing layers, and a peelable release liner layer (17) that underlies the adhesive layer with a first permanent heat seal (18) between the backing and the membrane about the perimeter of the reservoir and another peelable (impermanent) heat seal (19) between the membrane and the inner liner underlying the first permanent heat seal, the heat seals and peelable barrier layer providing barriers that isolate the drug formulation from the adhesive.