| 摘要 |
<p>Surface treatment of organic polymer materials and material surfaces with oligo- or polysaccharide as passivation agent for deliberate alteration of the sorption properties, the diffusion barrier function, lubricative wetting and/or biocompatibility of organic polymers, is described. The passivating agent is derivatized with chemical entities that allow tight adsorption and/or covalent binding of the passivating agent to organic polymers or elastomer surfaces. The passivating agent may be derivatized with a primary functional group to allow covalent surface passivation by photo- or thermal activation of the derivative. The passivating agent may comprise one or more secondary functional groups that allow covalent binding of probe molecules and receptors to the passivated surface. The surface treatment improves the biocompatibility of medical devices and the performance of bioanalytical systems. Its application for heterogeneous affinity based assays, biosensor analysis platforms, microcontact printing, and lubrication of medical devices is described. Devices comprising surface passivated PDMS organic polymer are also described.</p> |
