| 发明名称 |
NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS. |
| 摘要 |
<p>The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) ???? (NR1H3) and/or ???? (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.</p> |
| 申请公布号 |
MX2007008405(A) |
申请公布日期 |
2007.09.21 |
| 申请号 |
MX20070008405 |
申请日期 |
2006.01.09 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
LANNA LI;EVA-LOTTE LINDSTEDT-ALSTERMARK;PATRIK HOLM;KAY BRICKMANN;PERNILLA SANDBERG;MARIANNE SWANSON;ANDERS BROO;ROBERT JUDKINS;LARS WEIDOLF |
| 分类号 |
C07D275/03;A61K31/425;A61K31/427;A61K31/4427;A61K31/454;A61K31/4545;A61K31/506;A61K31/5377;A61P3/06;A61P3/10;A61P9/00;A61P9/10;A61P25/28;C07D;C07D275/02;C07D417/12;C07D417/14 |
主分类号 |
C07D275/03 |
| 代理机构 |
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