Method for producing reduced coenzyme Q10

摘要

Provided is a production method of Form I crystal of reduced coenzyme Q10 or a crystalline solid thereof, which is substantially free of Form II crystal, including a step of holding a solution containing reduced coenzyme Q10 at a temperature exceeding 47° C. for at least 60 minutes, and a step of crystallization thereafter.

主权项

1. A method of producing Form I crystal of reduced coenzyme Q10 or a crystalline solid thereof, comprising:
holding a solution comprising reduced coenzyme Q10 dissolved therein at a temperature of from 55° C. to 75° C. for at least 60 minutes; and crystallizing the reduced coenzyme Q10 to produce a Form I crystal of the reduced coenzyme Q10 or a crystalline solid thereof, which is substantially free of Form II crystal, wherein the crystallizing comprises cooling the solution, and the Form I crystal shows an endothermic peak near 48±1° C. when measured by DSC at temperature rise rate of 1° C./min.