| 摘要 |
1,195,384. Non-thrombogenic films and hollow artificial fibres. DOW CHEMICAL CO. 13 July, 1967 [21 July, 1966], No. 32307/67. Heading B5B. [Also in Divisions B1 and C3] Thrombogenicity is inhibited in articles of organic film or fibre-forming polymeric material having dialkylaminoalkyl groups attached to the polymer chains through ether linkages by reacting the material with an alkyl halide and reacting the resultant product with an alkali metal salt of a cationic group-containing antithrombogenic compound such as heparin or a heparinoid compound. The term "articles" is defined as meaning films, thin, pliable non- fibrous sheets and hollow fibres having an axial cavity extending throughout their length so that liquid can flow through the fibres from one end to the other. The dialkylaminoalkyl polymeric material may be prepared by converting at least a portion of the hydroxyl groups of a hydroxyl group-containing polymeric material to oxy alkali metal groups and reacting the product with a haloalkyl dialkyl amine. The hydroxyl group-containing material may be a cellulose, such as a regenerated cellulose, or may be prepared by treating a film-forming and/or a fibre-forming cellulose ester, such as cellulose acetate, with an aqueous solution of an excess of an alkali metal hydroxide. The aqueous solution may contain a water-soluble swelling agent for the cellulose ester, such as dimethyl sulphoxide, dimethylformamide, N-methylformamide, dimethylacetamide or tetramethylene sulphone or a ring-substituted derivative thereof. The article of the invention may be in the form of one or a bundle of hollow fibres. The hydroxyl group-containing polymeric material may be polyvinyl alcohol, hydroxy ethyl cellulose or hydroxyethylcarboxymethyl cellulose. Alternatively, polymeric materials that have grafted upon their surfaces hydroxy-containing materials may be employed, e.g. hydroxy terminated grafts of alkylene oxides on polyamides and polyesters. Normally the polymeric materials that are treated are in the desired article shape namely a film or fine hollow filaments, before being heparinized, but the polymeric material may be treated while in the form of granules, powders or other shapes and subsequently shaped into films or hollow filaments. The latter may be produced by melt spinning cellulose acetate plasticized with tetramethylene sulphone or a related ring-substituted derivative combined with a polyol. An artificial kidney may be comprised of a number of fine filamentary hollow fibres that have been treated according to the invention. |
