SULFONAMIDE DERIVATIVE AND PROCESS FOR PREPARING THE SAME

摘要

The present invention is directed to novel sulfonamide derivatives of the formula ¢I!: <IMG> ¢I! wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or a substituted or unsubstituted heterocyclic group, Q is a single bond, -O-, -S-, -SO-, -SO2- or -CH2-, Y is -O-, -S- or -NH-, Alk is lower alkylene or alkenylene, Z is -O- or -NH-, R is substituted or unsubstituted aromatic heterocyclic or aryl, R1 is H, trifluoromethyl, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, alkenyl, alkynyl, substituted or unsubstituted lower alkylthio, or alkoxy, or substituted or unsubstituted heterocyclic or aryl, or pharmaceutically acceptable salts thereof. The derivatives of the present invention are useful in the prophylaxis or treatment of disorders associated with endothelin activities such as hypertension, pulmonary hypertension, renal hypertension, Raynaud disease, bronchial asthma, gastric ulcer, chronic heart failure, etc.