| 摘要 |
A method of producing double-stranded nucleic acid derivatives having RNA as the parent body (the total molecular size distribution of which is from 4S to 13S expressed as sedimentation constant value of, alternatively, is such that the derivatives have base numbers in the range 50 to 10,000) including sizing nucleic acid polymers and subsequently combining them. Before combination the sized polymers may be subjected to ion-exchange treatment (to effect a size determination). Such treatment with ion-exchange will also serve to remove pyrogens from nucleic acid derivatives intended for administration by injection. |
