NEW OPTICALLY ACTIVE UNSATURATED CARBOXYLIC ACID DERIVATIVE AND ITS PRODUCTION

摘要

PURPOSE: To provide the subject new compound expected to be usable as a synthetic intermediate for various optically active compounds such as an optically active substance useful as a synthetic intermediate for physiologically active substances such as pharmaceuticals and agrochemicals. CONSTITUTION: This carboxylic acid derivative is a compound of formula I (R is a 1-6C alkyl), e.g. (R)-2-methyl-5-methylene-hexanoic diacid 6-monomethyl ester. The compound of formula I can be produced by treating a racemic compound of formula II with cultured product, cell or treated cell of a microorganism capable of asymmetrically hydrolyzing an ester bond (e.g. microorganism belonging to the genus Pseudomonas or Escherichia or a gene-manipulated microorganism transformed by a gene coding for an enzyme causing asymmetric hydrolysis of an ester bond).