QUINOLONE SULFONIMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION

摘要

The present invention relates to novel quinolone sulfonimides of formula (I), wherein the substituent containing A is bound at the 5-, 6- or 7-position; the substituent containing COHNSO>2< is bound at the 1- or 2-position of the 4-quinolone ring; R?1> is bound at the 1- or 2-position of the 4-quinolone ring and is hydrogen, alkyl, -OH, -OCH3, -CH2X, X is -OH, -OCH3 or -COOR<8>, R<8> being hydrogen or alkyl; R<2> is hydrogen, fluorine, chlorine, alkyl or -OCH3; R<3> is hydrogen, fluorine, chlorine, alkyl or -OCH3; R<4> is hydrogen, fluorine, chlorine, or -OCH3; R<5> is hydrogen or methyl; R<6> is alkyl, cycloalkyl or phenylalkyl; R<7> is hydrogen, alkyl, -OCH3 or -CH2X; A is oxygen, methylene or -NR<9>-; R<9> is hydrogen or methyl. Said compounds having a leukotriene-antagonistic activity and they can be used as antiinflammatory and antiallergic agents or in the treatment of cardiovascular diseases.