New well tolerated glyoxylic acid thioamide derivatives

摘要

Glyoxylic acid thioamide derivatives of formula (I) are new. A = a bond or optionally substituted alkylene; R<1> = cycloalkyl, cycloalkenyl, aryl or heterocyclyl; R<2> = hydroxy or amino; alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylamino, dialkylamino, arylamino, cycloalkyl, cycloalkenyl, cycloalkoxy, cycloalkenyloxy, cycloalkylamino, aryl, arylalkyl, arylalkoxy or heterocyclyl (all optionally substituted); R<3> = H; alkyl, alkenyl, alkynyl or cycloalkyl (all optionally substituted); R<4> = cycloalkyl, cycloalkenyl, aryl or heterocyclyl (all optionally substituted).