| 摘要 |
PCT No. PCT/DK95/00363 Sec. 371 Date Feb. 12, 1997 Sec. 102(e) Date Feb. 12, 1997 PCT Filed Sep. 11, 1995 PCT Pub. No. WO96/07324 PCT Pub. Date Mar. 14, 1996Contact lens are cleaned and disinfected by contacting with an enzyme that functions as a cleaning agent by degrading deposits on the lens, and with an enzyme inhibitor that inhibits remaining enzyme activity and a mild disinfecting agent. If rinsing of the lens is not carried out after cleaning and disinfecting, this procedure prevents eye damage by inhibiting remaining enzyme activity and using a mild disinfectant. Preferred enzymes are proteases such as an acidic aspartic protease, a cysteine protease, a serine protease or a metalloprotease, and preferred enzyme inhibitors function both as an inhibitor and as a mild disinfectant such as chloramine-T, chloramine-B, bacitracin or aryl boronic acids. In a preferred method, the enzyme is subtilisin A and the enzyme inhibitor and disinfectant is chloramine-T. The method may be carried out with a solution containing the enzyme and a tablet containing the enzyme inhibitor and disinfectant or with two tablets where one contains the enzyme and the other contains the enzyme inhibitor and disinfectant or with a multi-layer tablet where an outer layer contains the enzyme and an inner layer contains the enzyme inhibitor and disinfectant. The inner and outer layers may be separated by a barrier layer made of a water soluble polymer. A controlled release tablet is preferred.
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