OXAINDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

摘要

This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (I) (I) <IMG> wherein R1 represents lower C1-4alkyl, lower C1-4 alkoxy or lower C3-6 cycloalkyl, R2 stands for hydrogen, lower C1-4 alkyl or lower C3-6 cycloalkyl, R3 stands for hydrogen, lower C1-4 alkyl, lower C1-4 alkoxy or benzyloxy, X denotes hydrogen, an aliphatic C1-4-acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C1-4-alkoxy group(s) or a group of the formula R5R6=N-R7, wherein R5, R6 and R7 each represent lower C1-4 alkylene, or R5 and R6 together with the nitrogen atom to which they are attached form a piperidyl or morpholinyl group, A and B together form an ethylene or a vinylene group, and n is 1,2 or 3, and have a strong 5-lipoxygenase (5-LO) enzyme inhibiting activity.