发明名称 KAPPA-OPIATE AGONISTS FOR INFLAMMATORY BOWEL DISORDERS
摘要 The invention relates to pharmaceutical preparations which are suitable for the treatment of inflammatory bowel disorders and contain at least one compound of the formula I <IMG> (I) in which R1 is Ar, cycloalkyl having 3-7 C atoms or cyclo alkylalkyl having 4-8 C atoms, R R1 and R <IMG> , R3 is H, OH, OA or A, R4 is A or phenyl which can optionally be mono or disubstituted by Hal, OH, OA, CF3, NO2, NH2, NHA, NHCOA, NHSO2A or NA2, R5 is OH, CH2OH, R6 and R7 in each case independently of one another are H, Hal, OH, OA, CF3, NH2, NHA, NA2, NHCOA, NHCONH2, NO2 or methylenedioxy, A is alkyl having 1-7 C atoms, Ar is a mono- or bicyclic aromatic radical which can optionally contain an N, O or S atom and can be mono-, di- or trisubstituted by A, Hal, OH, OA, CF3, NH2, NHA, NA2, NHCOA and/or NHCONH2, D is CH2, O, S, NH, NA, -CH2-CH2-, -CH=CH-, -CH2NH-, -CH2-NA- or a bond and Hal is F, Cl, Br or I, and/or one of its physiologically acceptable salts and/or one of its glycosylated derivatives, and at least one physiologically acceptable excipient or auxiliary.
申请公布号 CA2179955(A1) 申请公布日期 1996.12.29
申请号 CA19962179955 申请日期 1996.06.26
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG 发明人 BARBER, ANDREW;SEYFRIED, CHRISTOPH;BARTOSZYK, GERD;GOTTSCHLICH, RUDOLF
分类号 C07D207/08;A61K31/40;A61K31/4015;A61K31/4025;A61P1/00;A61P1/04;A61P29/00;A61P43/00;C07D207/12;(IPC1-7):A61K31/40;A61K31/435 主分类号 C07D207/08
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