NITRODERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS

摘要

A compound having the structure (Formula I), wherein Y is -Y¹-Y²-Y³-Y⁴-Y⁵-; Y¹ is C(O) or C(R¹R²); Y² is O, C(O), P(O)(OH) or CH₂, provided that when Y¹ is C(O), Y² is not C(O); R¹ is selected from the group consisting of hydrogen and C_1-4 alkyl; R² is selected from the group consisting of hydrogen, C_1-4 alkyl, and -OC(O)C_1-4 alkyl; Y³ is O, C(O) or CH₂, provided that when Y² is C(O), then Y³ is not C(O), and further provided that when Y² is O, then Y³ is not O; Y⁴ is O or CH₂ or is absent, provided that when Y³ is O, then Y⁴ is not O; Y5 is -(CH₂) _1-2-(X)_{0- l}-(CH₂)_0-l- or is absent; X is -O- or -CR³R⁴-; and R³ and R⁴ are independently selected from the group consisting of hydrogen and C₁-C₄ alkyl; or a pharmaceutically acceptable salt thereof, which is useful for treating hypertension.