| 发明名称 | Antibody molecules to dengue virus and uses thereof | ||
| 摘要 | Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus. | ||
| 申请公布号 | US9365639(B2) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201514921701 | 申请日期 | 2015.10.23 |
| 申请人 | VISTERRA, INC. | 发明人 | Robinson Luke;Shriver Zachary;Myette James;Babcock Gregory;Viswanathan Karthik |
| 分类号 | C07K16/10;C12N7/00;G01N33/569;A61K39/42;A61K45/06;A61K39/00 | 主分类号 | C07K16/10 |
| 代理机构 | Lando & Anastasi, LLP | 代理人 | Lando & Anastasi, LLP |
| 主权项 | 1. A method of neutralizing dengue virus, the method comprising contacting the dengue virus with an antibody molecule capable of binding to the dengue virus, wherein the antibody molecule comprises: (a) a heavy chain immunoglobulin variable region segment comprising: a CDR1 comprising the sequence DVYMS (SEQ ID NO: 3),a CDR2 comprising the sequence RIDPENGDTKYDPKLQG (SEQ ID NO: 4), anda CDR3 comprising the sequence GWEGFAY (SEQ ID NO: 5); and (b) a light chain immunoglobulin variable region segment comprising: a CDR1 comprising the sequence RASENVDKYGNSFMH (SEQ ID NO: 6),a CDR2 comprising the sequence RASELQW (SEQ ID NO: 7), anda CDR3 comprising the sequence QRSNEVPWT (SEQ ID NO: 8), thereby neutralizing dengue virus. | ||
| 地址 | Cambridge MA US | ||