| 摘要 |
The present invention relates to compounds of Formula I;
or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. |
| 主权项 |
1. A compound represented by Formula I: or a pharmaceutically acceptable salt, thereof, wherein: Ar is an phenyl group; Ar1 is an phenyl or furanyl group; X is R is selected from the group consisting of lower alkyl, OC(O)R4, (CR1R2)aC(O)OR3, (CR1R2)aOR3, (CR1R2)aN(R4)C(O)R3, (CR1R2)aC(O)N(R3)2, (CR1R2)aN(R4)C(O)OR3, (CR1R2)aN(R4)C(O)N(R3)2, (CR1R2)aN(R3)2, wherein N(R3)2 may form a heterocyclic ring optionally substituted with one or more of halogen and lower alkyl; R1, R2 and R4 are independently selected from the group consisting of hydrogen, halogen and lower alkyl; R3 is selected from the group consisting of hydrogen and lower alkyl; R5 is selected from hydrogen and lower alkyl; R6 is selected from hydrogen and lower alkyl; a is 0 or an integer of from 1 to 4; and n is 0 or an integer of from 1 to 4. |
