Electroporation ablation apparatus, system, and method

摘要

A surgical instrument, such as an endoscopic or laparoscopic instrument, includes an ablation device. The ablation device includes an elongate relatively flexible member having a proximal end and a distal end, the flexible member includes at least a first working channel. A first and second electrode extends from a working channel at the distal end of the flexible member. The first and second electrodes are adapted to be endoscopically located in a tissue treatment region. The first and second electrodes are adapted to couple to an electrical waveform generator to receive an irreversible electroporation electrical waveform sufficient to ablate tissue located between the first and second electrodes. The waveform parameters of the irreversible electroporation electrical waveform are determined based on image information received from the tissue treatment region.

主权项

1. An apparatus, comprising:
an elongate shaft; a first channel and a second channel defined in the elongate shaft; a first probe positioned at least partially within the first channel, wherein the first probe comprises a first distal-most portion and defines a first longitudinal axis extending to the first distal-most portion, wherein the first distal-most portion is laterally aligned with the first longitudinal axis, and wherein the first probe is rotatable within the first channel; a first electrode coupled to the first distal-most portion of the first probe and laterally offset from the first longitudinal axis, wherein the first electrode is structured to rotate about the first longitudinal axis via the first probe, and wherein the first electrode is configured to couple to a bipolar electrical waveform generator; a first conductor external to the first channel, wherein the first conductor is electrically coupled to the first electrode, and wherein the first conductor extends from a positive pole of the bipolar electrical waveform generator to the first electrode; a second probe positioned at least partially within the second channel, wherein the second probe comprises a second distal-most portion and defines a second longitudinal axis extending to the second distal-most portion, and wherein the second distal-most portion is laterally aligned with the second longitudinal axis; a second electrode coupled to the second distal-most portion of the second probe and laterally offset from the second longitudinal axis, wherein the second electrode is configured to couple to the bipolar electrical waveform generator; a second conductor external to the second channel, wherein the second conductor is electrically coupled to the second electrode, and wherein the second conductor extends from a negative pole of the bipolar electrical waveform generator to the second electrode; and an adjustable ablation region defined between the first and second electrodes, wherein the ablation region is adjustable by rotating the first probe.