Self-renewal promoter for neural stem cells and method for using same

摘要

An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained in a culture supernatant of endothelial progenitor cells derived from bone marrow has an effect of promoting the self-renewal of neural stem cells. Accordingly, ECF-L can be used as an ingredient of an agent for promoting the self-renewal of the neural stem cells, a pharmaceutical composition for growing the neural stem cells, and a pharmaceutical composition for treating a disease associated with neural dysfunction.

主权项

1. A method of culturing neural stem cells, comprising:
culturing the neural stem cells in a medium comprising an effective amount of a chitinase 3-like 3 protein to promote self-renewal of the neural stem cells in culture, wherein the chitinase 3-like 3 protein is a recombinant protein.