Crosslinked zwitterionic hydrogels

摘要

Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

主权项

1. A crosslinked hydrogel, comprising a crosslinked polymer having repeating units and a plurality of crosslinks, wherein each crosslink is represented by the formula: wherein R1 and R2 are independently selected from the group consisting of hydrogen, fluorine, trifluoromethyl, C1-C6 alkyl, and C6-C12 aryl groups; R3 is selected from the group consisting of C1-C6 alkyl, C6-C12 aryl, CH2═C(R1)-L1-, CH2═C(R2)-L2-, or R3 is the residual portion of a third crosslink, -L1-CR1—CH2— or -L2-CR2—CH2—; L1 and L2 are independently selected from the group consisting of —C(═O)O—(CH2)n— and —C(═O)NH—(CH2)n—, wherein n is an integer from 1 to 20; L3 is —(CH2)n—, where n is an integer from 1 to 20; A1 is C, S, SO, P, or PO; x is an integer from about 5 to about 10,000; X− is the counter ion associated with the N+ cationic center; and M+is a counterion associated with the (A=O)O− anionic center.