Methods for treating parkinson's disease by optically stimulating target cells

摘要

Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.

主权项

1. A method for treating Parkinson's Disease in an individual, the method comprising:
a) implanting into the individual a device comprising:
i) a recombinant expression vector comprising a nucleotide sequence encoding a Volvox carteri light-activated ion channel (VChR1) protein to provide localized depolarization of afferent axons of the subthalamic nucleus (STN); andii) a light-delivery mechanism,wherein the VChR1 protein is produced in the afferent axons; and b) activating the VChR1 protein with the light-delivery mechanism, thereby depolarizing the afferent axons and treating the disease.