| 主权项 |
1. A compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein each of R1, R2 and R3 is OH; wherein R6 is —OR6a or —OC(═O)R6b; and each of R4 and R5 is independently —H, alkyl, alkylamino, alkynyl, alkenyl, cyano, cycloalkyl or heterocyclyl, and wherein optionally each of the alkyl, alkylamino, alkynyl, alkenyl, cycloalkyl and heterocyclyl is substituted by one or more substituents independently selected from —H, —F, —Cl, —Br, —I, hydroxy, cyano, amino, alkynyl, alkenyl, carboxy, mercapto, alkylamino, —SR13, —C(═O)R13, —C(═O)OR13, —OC(═O)R13, —OC(═O)OR13, —NHC(═O)R13, —C(═O)NHR13, trifluoromethyl, —S(═O)2R13, —S(═O)R13, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy and heteroarylalkoxy, or R4 and R5, together with the carbon atom to which they are attached, form a ring A, wherein the ring A is a saturated or unsaturated, 3- to 8-membered ring, and wherein the ring A optionally contains one or more atoms or atomic groups independently selected from —NH—, —O—, —S—, —C(═O)— and —S(═O)—, and wherein the ring A is optionally substituted by one or more substituents independently selected from —H, —F, —Cl, —Br and —I; or wherein R4 is —H; and R5and R6, together with the carbon atom to which they are attached, form a ring B, wherein the ring B is a saturated or unsaturated, 3- to 8-membered ring, and wherein the ring B optionally contains one or more atoms or atomic groups independently selected from —NH—, —O—, —S—, —C(═O)— and —S(═O)—, and wherein the ring B is optionally substituted by one or more substituents independently selected from —H, —F, —Cl, —Br and —I; wherein R6a is —H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, and wherein optionally each of the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl is substituted by one or more substituents independently selected from —H, —F, —Cl, —Br, —I, hydroxy, cyano, amino, alkynyl, alkenyl, carboxy, mercapto, trifluoromethyl, —SR14, —C(═O)R14, —C(═O)OR14, —OC(═O)R14, —OC(═O)OR14, —NHC(═O)R14, —S(═O)2R14 and —S(═O)R14; wherein R6b is alkyl, alkoxy, arylalkoxy or heteroarylalkoxy, and wherein optionally each of the alkoxy, arylalkoxy or heteroarylalkoxy is substituted by one or more substituents independently selected from —H, —F, —Cl, —Br, —I, hydroxy, cyano, amino, alkynyl, alkenyl, carboxy and mercapto; wherein R7 is —H, alkyl, alkylamino, alkynyl or alkenyl; wherein R8 is —H, alkylamino, alkynyl or alkenyl; wherein at least one of R4, R5, R7 and R8 is not H; wherein R9 is —H, —F, —Cl, —Br, —I or C1-6 alkyl; wherein R10 is C1-6 alkoxy or C1-6 haloalkoxy; wherein Y is methylene, which is optionally substituted by one or more substituents independently selected from —H, —F, —Cl, —Br and hydroxy; wherein each R11 is independently —H, —F, —Cl, —Br, —I or C1-6 alkoxy; wherein n is 1, 2 or 3; wherein each R12 is independently —H, —F, —Cl or —I; wherein m is 1, 2, 3 or 4; and wherein each R13 and R14 is independently —H, alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl, and wherein optionally each of the alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl is substituted by one or more substituents independently selected from —H, —F, —Cl, —Br, —I, hydroxy, amino, cyano, alkyl, alkoxy, alkylamino, hydroxyalkyl, cycloalkoxy, aryloxy, heteroaryloxy, heterocycloalkoxy, trifluoromethyl, carboxy and —C(═O)O-alkyl. |
