Rilyazine derivatives and compositions for the treatment of cancer

摘要

The present application discloses Rilyazine analogs, methods for their preparation, and the treatment of cancer by the administration of an effective amount of the Rilyazine analogs to a patient in need thereof.

主权项

1. A compound selected from the group consisting of: wherein: each R1 is independently selected from the group consisting of hydrogen, halo, nitro, trifluoromethyl, trifluoromethoxy, methoxy, carboxy, —NH2, —OH, —SH, —NHCH3, —N(CH3)2, —SCH3, —CN, (C1-C6)alkyl, substituted (C1-C6)alkyl, aryl and heteroaryl; each R2 is independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C1-C12)alkoxy, —C(O)(C1-C12)alkyl, (C3-C10)cycloalkyl, aryl, aryloxy, heteroaryl and heteroaryloxy, wherein each of (C1-C12)alkyl, (C1-C12)alkoxy, —C(O)(C1-C12)alkyl, (C3-C10)cycloalkyl, aryl, aryloxy, heteroaryl and heteroaryloxy is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of halo, nitro, trifluoromethyl, trifluoromethoxy, methoxy, carboxy, —NH2, —OH, —SH, —NHCH3, —N(CH3)2, -SCH3, —CN, (C1-C6)alkyl, substituted (C1-C6)alkyl, aryl and heteroaryl; and each R3 is independently selected from the group consisting of hydrogen, halo, nitro, trifluoromethyl, trifluoromethoxy, methoxy, carboxy, —NH2, —OH, —SH, —NHCH3, —N(CH3)2, —SCH3, —CN, (C1-C6)alkyl, substituted (C1-C6)alkyl, aryl and heteroaryl; as a single stereoisomer, a mixture of stereoisomers, and a pharmaceutically acceptable salt thereof.