| 发明名称 |
Direct differentiation of cardiomyocytes from embryonic stem cells |
| 摘要 |
The present invention relates to the induction of differentiation in human embryonic stem (hES) cells to cardiomyocytes and factors such as prostaglandin I2 (PGI2), Fgf 9, Bmp6, Bmp4, Scf, Igf2, and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from hES cells is also provided wherein the media contains these factors. Genes that are upregulated in the process of cardiomyocyte differentiation are also provided. |
| 申请公布号 |
US9404085(B2) |
申请公布日期 |
2016.08.02 |
| 申请号 |
US201213651151 |
申请日期 |
2012.10.12 |
| 申请人 |
ES Cell International PTE LTD. |
发明人 |
Davidson Bruce Paul;Graichen Ralph Eberhard;Zweigerdt Robert;Xu Xiuqin;Mummery Christine Lindsay;Sun William |
| 分类号 |
C12N5/02;C12N5/077;G01N33/50;C12N5/00;A61K35/12 |
主分类号 |
C12N5/02 |
| 代理机构 |
|
代理人 |
Kauppinen Krista P.;Mittler E. Stewart |
| 主权项 |
1. A cell-free culture medium for differentiating stem cells to cardiomyocytes, comprising a prostaglandin or an analog or functional equivalent thereof. |
| 地址 |
Singapore SG |
