发明名称 |
Reagent controlled stereoselective glycosylation |
摘要 |
Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups. |
申请公布号 |
US9403862(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201414445917 |
申请日期 |
2014.07.29 |
申请人 |
Trustees of Tufts College |
发明人 |
Bennett Clay S.;Issa John P.;Lloyd Dina |
分类号 |
C07H1/00;C07H5/10;C07H15/18;C07H15/207;C07H9/04 |
主分类号 |
C07H1/00 |
代理机构 |
Foley Hoag LLP |
代理人 |
Gordon Dana M.;Foley Hoag LLP |
主权项 |
1. A method of forming a glycosidic bond, comprising:
combining a first solvent, a reducing sugar, and a first strong Bronsted base, thereby forming a first reaction mixture; combining a sulfonylating agent and the first reaction mixture, thereby forming a glycosyl sulfonate; combining a second solvent, a glycosyl acceptor, and a second strong Bronsted base, thereby forming a second reaction mixture; and combining the glycosyl sulfonate and the second reaction mixture, thereby forming a glycosidic bond; wherein the reducing sugar is a pyranose; the sulfonylating agent is selected from the group consisting of tosyl 4-nitroimidazole, benzenesulfonyl 4-nitroimidazole, and p-toluenesulfonic anhydride; and the glycosidic bond is formed with greater than or equal to 90% stereoselectivity for a β linkage. |
地址 |
Boston MA US |