Filtration and use of metal nanoparticles as non-optical tags in chemical-, bio-chemical sensors and micro-electromechanical devices

摘要

This disclosure provides methods to use nanoparticles as non-optical tags for detecting a change in mass. chemical sensing or bio-sensing events or reaction upon conjugation of nanoparticles onto a thermoresistor heat sensor. Particularly described is the use of metal nanoparticles in thermal sensors, thermal bio-sensors, and sensing pixel arrays for multiple analyte sensing. In addition, an asymmetric filter is disclosed that allows size separation of molecules from nanoparticles. The asymmetric filter is a porous membrane that is designed to have a small pore size in one size and a large pore size on the other side.

主权项

1. A nanoengineered device, comprising:
a base substrate coated with a non-conductive layer; wherein at least one conductive layer is deposited over the non-conductive layer, wherein the device response depends on the resistivity of the conductive layer; wherein a heat source is embedded under the conductive layer; wherein the heat source changes the resistivity of the conductive layer; wherein the heated conductive layer receives at least one metal nanoparticle, further wherein the at least one metal nanoparticle is precipitated due to its binding to the device, wherein the at least one metal nanoparticle forms electrically non-conductive junctions to device, further wherein the at least one metal nanoparticle operably changes resistivity and output voltage of sensor, wherein the device response is measured via two embedded metal electrodes in the non-conductive layer.